Scientists genetically create a new Pokémon, Mewtwo, but the results are horrific and disastrous.

A crystal catastrophe is unleased upon Greenfield, and Ash, Pikachu, and friends must figure out how to undo the damage to the once-beautiful town. But the unthinkable happens when Ash's mother is kidnapped by the powerful Entei, a Pokémon thought to have existed only in legend. Now Ash must go to her rescue, uncertain of what he'll uncover when he unlocks the real secret power behind the unbelievable turn of events: a young girl whose dream world...

Our heroes come across an unofficial Pokémon Contest in a small village-and after an unusual good deed, Team Rocket's Jessie wants to borrow Ash's Aipom to compete!

After Paul's victory at the Oreburgh Gym, it's Ash's turn to face Gym Leader Roark and his powerful Rock-type Pokémon.

On their way to Eterna City, our heroes meet an unusual Nurse Joy who has a family: two little girls who want to be just like their mom!

As Dawn sets off to find an injured Pikachu's Trainer, Ash hears the story from Professor Rowan and sets off to find Dawn-and reunites with Brock along the way!

On their way to Hearthome City, our heroes cross paths with Cynthia, the Champion of the Sinnoh League-and she's battling Ash's rival Paul!

On their way to Oreburgh City, our heroes discover that something is happening to the flying Pokémon who live in the forest, and they decide to investigate.

When our heroes encounter the ruthless Pokémon Hunter J, they are forced into an unusual alliance to deal with the threat!

When our heroes arrive in Eterna City for Ash's next Gym battle, they witness the aftermath of a major theft at the local museum of history!